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- Title
Editorial: Infiltrative pattern of invasion is independently associated with shorter survival and desmoplastic stroma markers FAP and THBS2 in mucinous ovarian carcinoma.
- Authors
Parra‐Herran, Carlos; Dundr, Pavel; McCluggage, W Glenn
- Abstract
Mucinous ovarian carcinoma (MOC) is a rare type of ovarian cancer with a better prognosis compared to other types. However, some patients with stage I disease experience tumor recurrence and poor outcomes. Recent studies have shown that the growth pattern of MOC, either expansile or infiltrative invasion, is a better predictor of clinical behavior than tumor grading. A study published in Histopathology found that MOCs with infiltrative invasion were associated with a higher risk of death, independent of other factors. The study also confirmed that MOCs with expansile invasion have better outcomes. The study recommends including the pattern of invasion in histopathologic reporting and risk stratification for MOC patients. Additionally, the study found that stromal markers FAP and THBS2 were more commonly expressed in MOCs with infiltrative invasion, which was associated with worse disease-specific survival. The study suggests that evaluating growth pattern and stromal markers can aid in the classification and understanding of biological differences in MOC. The authors emphasize the need for standardized criteria and increased awareness among pathologists for evaluating growth pattern in MOC. Pathologic staging and p53 mutation-type staining were also found to be important prognostic factors in MOC. The authors envision a future where patient management is based on important tumor parameters like growth pattern and p53 status, which can be easily incorporated into routine practice and may lead to improved patient stratification and tailored approaches.
- Subjects
MUCINOUS adenocarcinoma; RENAL cell carcinoma; MEDICAL personnel; FALLOPIAN tubes; OVARIAN epithelial cancer; P53 antioncogene; SYMPTOMS; BREAST
- Publication
Histopathology, 2024, Vol 84, Issue 7, p1092
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/his.15181