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- Title
Fetal Valproate Syndrome with Limb Defects: An Indian Case Report.
- Authors
Goyal, Manisha; Gupta, Ashok; Sharma, Manish; Mathur, Priyanshu; Bansal, Naresh
- Abstract
Epilepsy is a common disorder and exposure to antiepileptic drugs during pregnancy increases the risk of teratogenicity. Older AEDs such as valproate and phenobarbital are associated with a higher risk of major malformations in the fetus than newer AEDs like lamotrigine and levetiracetam. Exposure to valproic acid during first trimester can result in fetal valproate syndrome (FVS), comprising typical facial features, developmental delay, and a variety of malformations such as neural tube defects, cardiac and genitourinary malformations, and limb defects. We are presenting an Indian case of FVS with major limb defects.
- Subjects
ABNORMALITIES in the anatomical extremities; VALPROIC acid; EPILEPSY in pregnancy; ANTICONVULSANTS; FIRST trimester of pregnancy; PHENOBARBITAL
- Publication
Case Reports in Pediatrics, 2016, p1
- ISSN
2090-6803
- Publication type
Case Study
- DOI
10.1155/2016/3495910