We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nucleolar targeting runs on GTP cycles.
- Authors
Swaminathan, Sowmya
- Abstract
The article informs that a paper in the January 17 issue of the "Journal of Cell Biology," reported a new mechanism for localizing nucleolar proteins, GTP binding and hydrolysis. Many proteins reside in the nucleolus, the site of rRNA biogenesis, but comparatively little is known about how these proteins reach this site, what keeps them there or what causes them to depart. In their new study, Robert Tsai and Ronald McKay focused on nucleostemin, a nucleolar GTP-binding protein that regulates cell proliferation. They observed that nucleostemin rapidly shuttles between the nucleolus and nucleoplasm, and so wanted to address how this cycling is controlled.
- Subjects
PROTEINS; BIOMOLECULES; CELL nuclei; ORIGIN of life; CELL division; CELL proliferation; CELL growth
- Publication
Nature Cell Biology, 2005, Vol 7, Issue 3, p217
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb0305-217