We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The many faces of filamin: A versatile molecular scaffold for cell motility and signalling.
- Authors
Yuanyi Feng; Walsh, Christopher A.
- Abstract
Filamins were discovered as the first family of non-muscle actin-binding protein. They are lage cytoplasmic proteins that cross-link cortical actin into a dynamic three-dimensional structure. Filamins have also been reported to interact with a large number of cellular proteins of great functional diversity, suggesting that they are unusually versatile signalling scaffolds. More recently, genetic mutations in filamin A and B have been reported to cause a wide range of human diseases, suggesting that different diseases highlight distinct filamin interactions.
- Subjects
CYTOPLASM; ACTIN; BIOMOLECULES; CARRIER proteins; MOLECULAR biology; CYTOLOGY
- Publication
Nature Cell Biology, 2004, Vol 6, Issue 11, p1034
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb1104-1034