We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.
- Authors
Yang, Yu-Ting; Wang, Chia-Lin; Van Aelst, Linda
- Abstract
Neurogenesis in the developing neocortex relies on the ability of radial glial progenitor cells (RGCs) to switch from proliferative to differentiative neuron-generating divisions, but the molecular mechanisms that control this switch in a correct temporal manner are not well understood. Here, we show that DOCK7, a member of the DOCK180 family of proteins, regulates RGC proliferation versus differentiation. Silencing of DOCK7 in RGCs of developing mouse embryos impedes neuronal differentiation and maintains cells as cycling progenitors. In contrast, DOCK7 overexpression promotes RGC differentiation to basal progenitors and neurons. We further present evidence that DOCK7 influences neurogenesis by controlling apically directed interkinetic nuclear migration of RGCs. DOCK7 exerts its effects by antagonizing the microtubule growth-promoting function of the centrosome-associated protein TACC3. Thus, DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from RGCs during cortical development.
- Subjects
DEVELOPMENTAL neurobiology; NEOCORTEX; PROGENITOR cells; LABORATORY mice; MICROTUBULES
- Publication
Nature Neuroscience, 2012, Vol 15, Issue 9, p1201
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.3171