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- Title
Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice.
- Authors
Elliott, Evan; Ezra-Nevo, Gili; Regev, Limor; Neufeld-Cohen, Adi; Chen, Alon
- Abstract
DNA methylation regulates gene transcription and has been suggested to encode psychopathologies derived from early life stress. We found that methylation regulated the expression of the Crf (also known as Crh) gene and that chronic social stress in adult mice induced long-term demethylation of this genomic region. Demethylation was observed only in the subset of defeated mice that displayed social avoidance and site-specific knockdown of Crf attenuated the stress-induced social avoidance.
- Subjects
CORTICOTROPIN releasing hormone; NEUROPEPTIDES; PITUITARY hormone releasing factors; NUCLEIC acids; LABORATORY mice
- Publication
Nature Neuroscience, 2010, Vol 13, Issue 11, p1351
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.2642