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- Title
Glutamate release during LTD at cerebellar climbing fiber–Purkinje cell synapses.
- Authors
Shen, Ying; Hansel, Christian; Linden, David J.
- Abstract
It is widely thought that persistent, use-dependent alterations in synaptic strength such as long-term synaptic potentiation (LTP) and depression (LTD) underlie at least a portion of memory traces in the brain, but the exact cellular locus of expression for these alterations remains to be determined. They could be expressed presynaptically as a decrease in transmitter release, postsynaptically as a decrease in the synaptic current evoked by a fixed delivery of transmitter, as an increase in the number of functional synaptic contacts, or by a combination of these mechanisms. Here we report that LTD at the climbing fiber–Purkinje cell synapse in rat cerebellum was not associated with changes in a synaptic cleft glutamate transient, indicating that this type of LTD is most likely expressed postsynaptically.
- Subjects
SYNAPSES; PURKINJE cells; PROTEIN kinase C
- Publication
Nature Neuroscience, 2002, Vol 5, Issue 8, p725
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn895