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- Title
Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398.
- Authors
Yu, Hong-ping; Shi, Lu-Yuan; Lu, Wen-Hong; Su, Yan-Hua; Li, Yuan-Yuan; Xu, Shun-Qing
- Abstract
The purpose of the present paper was to study the expression of cyclooxygenase-2 (COX- 2) in normal squamous epithelium, squamous dysplasia and squamous cell carcinoma (SCC) of the esophagus, to elucidate the role of COX-2 in esophageal carcinogenesis, and to evaluate the in vitro effect and mechanism of a COX-2 inhibitor, NS-398, in inducing growth inhibition and apoptosis of human esophageal cancer cells. Marked COX-2 expression was shown in SCC and esophageal squamous dysplasia, and no marked COX-2 expression was observed in the normal squamous epithelium, respectively. NS-398 could inhibit esophageal cells growth in a dose-dependent manner, induce apoptosis, and elevate caspase-3 activity in vitro. This study provides evidence that COX-2 is upregulated in the majority of cases of squamous dysplasia and SCC of esophagus, and that NS-398 can inhibit growth and induce apoptosis via activating caspase-3 activity in vitro. These results suggest that selective inhibitors of COX-2 may be an effective preventive and therapeutic option for esophageal carcinoma. © 2004 Blackwell Publishing Asia Pty Ltd
- Subjects
APOPTOSIS; CYCLOOXYGENASE 2; SQUAMOUS cell carcinoma; DYSPLASIA; ESOPHAGEAL cancer; CANCER cells
- Publication
Journal of Gastroenterology & Hepatology, 2004, Vol 19, Issue 6, p638
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/j.1440-1746.2004.03345.x