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- Title
Serum lipids and cardiac function correlate with nitrotyrosine and MMP activity in coronary artery disease patients.
- Authors
Bencsik, Péter; Sasi, Viktor; Kiss, Krisztina; Kupai, Krisztina; Kolossváry, Márton; Maurovich‐Horvat, Pál; Csont, Tamás; Ungi, Imre; Merkely, Béla; Ferdinandy, Péter
- Abstract
Aims Peroxynitrite-matrix metalloproteinase ( MMP) signalling has been shown to contribute to myocardial ischaemia/reperfusion injury and heart failure and to be influenced by hyperlipidaemia in preclinical models. Therefore, here we investigated the correlation between the markers of peroxynitrite- MMP signalling and hyperlipidaemia in patients with significant coronary stenosis. Methods Five minutes before percutaneous coronary intervention ( PCI), arterial blood samples were collected from 36 consecutive patients with coronary artery disease ( CAD) selected for elective PCI. Results Serum nitrotyrosine positively correlated with MMP-9 activity ( r = 0·54, P = 0·01), but not with MMP-2 activity. Nitrotyrosine positively correlated with total ( r = 0·58; P < 0·01) and LDL cholesterol ( r = 0·55; P < 0·01), serum triglyceride ( r = 0·47; P < 0·05), and creatinine ( r = 0·42; P < 0·05) and negatively correlated with HDL cholesterol ( r = −0·46; P < 0·05) and with left ventricular ejection fraction ( LVEF; r = −0·55; P < 0·05), respectively. MMP-2 activity correlated positively with total ( r = 0·55; P < 0·05) and LDL cholesterol ( r = 0·45; P < 0·05). In statin-treated patients, a significantly reduced serum nitrotyrosine was found as compared to statin naives; however, MMP activities and serum cholesterol levels were not different. MMP-9 activity correlated with urea nitrogen ( r = 0·42; P < 0·05) and LVEF ( r = −0·73; P < 0·01). Serum creatinine correlated negatively with LVEF ( r = −0·50, P < 0·01). Conclusions This is the first demonstration that (i) serum nitrotyrosine correlates with MMP-9 activity, (ii) lipid parameters correlate with nitrotyrosine and MMP-2 activity, (iii) myocardial function correlates with creatinine, nitrotyrosine and MMP-9 activity, and (iv) creatinine correlates with nitrotyrosine and urea nitrogen with MMP-9 activity in patients with CAD. Studying the biomarkers of peroxynitrite- MMP pathway in large prospective trials may reveal their diagnostic avails.
- Subjects
CORONARY disease; BLOOD lipids; HEART function tests; NITROTYROSINE; MATRIX metalloproteinases; ISCHEMIA; CREATININE; PATIENTS
- Publication
European Journal of Clinical Investigation, 2015, Vol 45, Issue 7, p692
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/eci.12458