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- Title
Risk Factors for Treatment Failure in Neonates With Skin and Soft Tissue Infection: A Retrospective Cohort Study.
- Authors
Patel, Purva; Foster, Catherine E.; Stimes, Grant; Lee, Su Rin; Wallace, Sowdhamini S.
- Abstract
We aimed to describe the frequency of treatment failure and associated risk factors for treatment failure amongst neonates with skin and soft tissue infections (SSTIs). We conducted a retrospective cohort study of neonates 0 to 28 days old with uncomplicated SSTIs presenting to the emergency department of a quaternary care children's hospital from 2009 to 2017. Data were collected via chart review. Skin and soft tissue infections included the following: cellulitis, abscess, mastitis, perirectal SSTI, carbuncle, and furuncle. Of the 202 neonates in the study, most were term, afebrile with mastitis, or perirectal SSTI. Treatment failure occurred in 8% (17/202) of neonates receiving oral antibiotics; 10 of these neonates had perirectal SSTIs and 2 had clindamycin and methicillin-resistant Staphylococcus aureus. Neonates with treatment failure had increased odds of having perirectal SSTIs (odds ratio [OR] = 4.08, 95% confidence interval [CI] = 1.46-11.31). Further studies are needed to identify strategies to prevent treatment failure in neonates with perirectal SSTIs.
- Subjects
ANTIBIOTICS; SOFT tissue infections; COMMUNICABLE diseases; RISK assessment; CELLULITIS; SKIN diseases; RETROSPECTIVE studies; HOSPITAL emergency services; TERTIARY care; ORAL drug administration; METHICILLIN-resistant staphylococcus aureus; LONGITUDINAL method; ODDS ratio; CLINDAMYCIN; MEDICAL records; ACQUISITION of data; ABSCESSES; TREATMENT failure; CONFIDENCE intervals; MASTITIS; CHILDREN
- Publication
Clinical Pediatrics, 2024, Vol 63, Issue 5, p689
- ISSN
0009-9228
- Publication type
Article
- DOI
10.1177/00099228231189132