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- Title
Bevacizumab-containing chemotherapy for non-small cell lung cancer patients: a population-based observational study by the Ibaraki thoracic integrative (POSITIVE) research group.
- Authors
Nakamura, Hiroyuki; Satoh, Hiroaki; Kaburagi, Takayuki; Nishimura, Yoshihiro; Shinohara, Yoko; Inagaki, Masaharu; Endo, Takeo; Saito, Takefumi; Hayashihara, Kenji; Hizawa, Nobuyuki; Kurishima, Koichi; Nawa, Takeshi; Kagohashi, Katsunori; Kishi, Koji; Ishikawa, Hiroichi; Ichimura, Hideo; Hashimoto, Toshio; Sato, Yukio; Sakai, Mitsuaki; Kamiyama, Koichi
- Abstract
To evaluate the efficacy and safety of bevacizumab-containing chemotherapy for non-small cell lung cancer (NSCLC), we performed a population-based observational study. The efficacy and safety of bevacizumab-containing chemotherapy for NSCLC patients were evaluated at 14 sites (17 hospital departments) in a prefecture of Japan between December 2009 and August 2011. Complete data sets were obtained from 159 patients with NSCLC. The median age was 66 years, and 34.0 % of the patients were 70 years or older. The overall response rate to bevacizumab therapy was 41.6 %, and the disease control rate was 78.5 %. In 88 patients who received bevacizumab-containing chemotherapy as first-line therapy, the response and disease control rates were 55.0 and 78.9 %, respectively. The incidence of clinically significant (grade 3 or more) adverse events was generally low: proteinuria occurred in 2 (1.3 %) patients, hypertension in 2 (1.3 %), hemoptysis in 1 (0.6 %), and interstitial pneumonia in 1 (0.6 %). The time to treatment failure (TTF) in the 159 patients was 169 days, and the median overall survival (OS) was 580 days. In patients who received bevacizumab-containing chemotherapy as first-line therapy, the TTF and OS were 152 and 520 days, respectively. The difference in TTF between patients who received bevacizumab-containing chemotherapy as first-line therapy and those who received it as second-line or later-line therapy was not significant ( p = 0.4971). With regard to first-line therapy, the difference in TTF between patients treated with carboplatin + pemetrexed + bevacizumab and those treated with carboplatin + paclitaxel + bevacizumab was not significant ( p = 0.9435). We deduced that bevacizumab-containing chemotherapy is effective against NSCLC and also tolerable in clinical practice.
- Subjects
BEVACIZUMAB; LUNG cancer; DRUG therapy; PROTEINURIA; HYPERTENSION
- Publication
Medical Oncology, 2012, Vol 29, Issue 5, p3202
- ISSN
1357-0560
- Publication type
Article
- DOI
10.1007/s12032-012-0318-5