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- Title
Role Of Red Cell Indices In The Differentiation Of Beta-Thalassemia Trait From Iron Deficiency Anemia In Duhok Province-IRAQ.
- Authors
ibrahim, Ameer jkhcey; Mohammed, Nawsherwan Sadiq; Sulaiman, Salar A.
- Abstract
Background and objective: Anemia is considered as one of the most widespread health issues; anemia is also a key clinical indicator of a number of other diseases and conditions. Hypochromia and microcytosis can be caused by many conditions. The most frequent cause of hypochromia and microcytosis is beta-thalassemia trait (β-TT) and iron deficiency anemia (IDA). The purpose of this research is to determine the accuracy of many distinct red blood cell (RBC) indices and formulae that are used to distinguish iron deficiency anemia from beta-thalassemia trait. Material and Method: A total of 300 blood samples of premarital couples with hypochromia (MCH<27pg) and Microcytosis (MCV<76fl) will be included. These samples will be evaluated using serum iron, complete blood count, and serum ferritin and hemoglobin electrophoresis. Results: Out of 300 individuals undergoing premarital screening, 154 (51.3%) IDA cases and 84(28%) of β-TT, and 62(20.7) other types of hypochromic microcytic anemia's were included in this research. Depending on the age, the mean ±SD age of IDA is 25.9 ±5.63years (range 20 - 66 years), β-TT cases with aged 24.88 ± 8.11 years (range 17 - 45 years). There was no discernible and significant difference between IDA instances and β-TT cases when it came to the age of the patients. Comparison of IDA and β-TT participants' red blood cell and hemoglobin profiles. Those with β-TT had higher RBC, and Hb counts, on average 5.91(0.75) and 12.3(1.52), compared to patients with IDA, whose counts varied from 154 (51.3%) to 4.93(0.65) and 11.35(9.3). (1.91). statistically, there is a significant difference between two groups (p<0.05). The RDW was considerably higher in IDA participants compared to ß-TT subjects. However, the mean± SD of RDWI (209.73±33.83) vs 152.85±23.93 was significantly higher in IDA cases as seen in ß-TT cases. MCV and MCH values for IDA patients (69.99±4.41) were significantly higher than those observed for β-TT patients (63.62±5.86). Whereas HCT level IDA was significantly lower than those observed for β-TT patients. Conclusion: RDW was considerably higher in IDA participants compared to ß-TT subjects. As well as, (RDW) above 16% is the best index of IDA. Our results show that RDWI, an easily accessible automated cell count-based index, is a good discriminator of IDA and β-TT. When it comes to diagnosing β-TT, criteria and formulae that are based on the cell count, in particular, the MCV and RBC counts and together with their associated indices, have a good capacity to discriminate between patients.
- Subjects
DIHOK (Iraq); IRAQ; IRON deficiency anemia; CELL differentiation; BETA-Thalassemia; ERYTHROCYTES; BLOOD cell count; FETAL hemoglobin; IRON
- Publication
Journal of Pharmaceutical Negative Results, 2022, Vol 13, p1379
- ISSN
0976-9234
- Publication type
Article
- DOI
10.47750/pnr.2022.13.S08.170