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- Title
Long noncoding RNAs in hematopoietic malignancies.
- Authors
Rodríguez-Malavé, Norma I.; Rao, Dinesh S.
- Abstract
Recent years have witnessed the discovery of several classes of noncoding RNAs (ncRNAs), which are indispensable for the regulation of cellular processes. Many of these RNAs are regulatory in nature with functions in gene expression regulation such as piwi-interacting RNAs, small interfering RNAs and micro RNAs. Long noncoding RNAs (lncRNAs) comprise the most recently characterized class. LncRNAs are involved in transcriptional regulation, chromatin remodeling, imprinting, splicing, and translation, among other critical functions in the cell. Recent studies have elucidated the importance of lncRNAs in hematopoietic development. Dysregulation of lncRNA expression is a feature of various diseases and cancers, and is also seen in hematopoietic malignancies. This article focuses on lncRNAs that have been implicated in the pathogenesis of hematopoietic malignancies.
- Subjects
NON-coding RNA; HEMATOLOGIC malignancies; CANCER cell proliferation; CANCER cell proteins; PIWI genes; GENE regulatory networks; GENETICS
- Publication
Briefings in Functional Genomics, 2016, Vol 15, Issue 3, p227
- ISSN
2041-2649
- Publication type
Article
- DOI
10.1093/bfgp/elv047