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- Title
Analysis of Myelodysplastic Syndrome Clones Arising After Multiple Myeloma: a Case Study by Correlative Interphase Cytogenetic Analysis.
- Authors
Kobayashi, Yukio; Nakayama, Michihiro; Uemura, Naoki; Takeyama, Kunihiko; Tobinai, Kensei; Takenaka, Takeaki; Choi, Soon Hee; Satoh, Hitoshi; Mori, Shigeo; Asano, Shigetaka
- Abstract
Background: A patient with multiple myeloma developed myelodysplastic syndrome (MDS). Chromosomal analysis performed after the development of MDS revealed monosomy of chromosome 9 in all the meta-phases. We wished to identify the extent of the clone with the chromosomal abnormality originating from MDS clone.Methods: A correlative interphase study by fluorescence in situ hybridization (FISH) was performed and we determined whether each lineage of cells obtained the molecular mark. The chromosome 9 classic α satellite region DNA was used as a probe for the FISH analysis in smear specimens stained with Wright-Giemsa stain.Results: Erythroblasts, granulocytes and myelocytes had only one signal, whereas myeloma cells showed two to four signals.Conclusion: This study visualized the spectrum of MDS clone. The results suggest that the origin of MDS is different from that of multiple myeloma, at least in this case.
- Publication
Japanese Journal of Clinical Oncology, 1999, Vol 29, Issue 8, p374
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/29.8.374