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- Title
Comparison of invasive andnoninvasive ventilation in acute exacerbation of COPD patients for ease of ventilation and weaning.
- Authors
Mohanty, Ranjita; Panda, Geetanjali; Sahoo, Ramachandra; Sahu, Rajesh Kumar
- Abstract
Aim:Acute exacerbation of the COPD can lead to respiratory failure which may requires assisted mechanical ventilation. But invasive mode of ventilation is usually associated with various complications like weaning failure, lengthy hospital stay and more mortality and morbidity. So wecompared noninvasive and invasive mechanical ventilation and their clinical outcome. Material & methods: 60 patients with acute exacerbation of COPD were randomized in to two groups of 30 each. One group received Non Invasive Ventilation (NIV) and other group received Invasive Mechanical Ventilation (IMV). Ease of ventilation was studied by serial estimation of tidal volume (TV), respiratory rate (RR), pressure support needed (PC above PEEP), PaCO2, pH at 0, 4th, 12th, 24th, 48th hr of mechanical ventilation and at the beginning of weaning. Results: The mean tidal volume requirement was more in NIV group when compared to IMV group. Mean of Respiratory rate at the time of admission in NIV group was high, and there was gradual reduction in respiratory rate over time. At the time of admission mean PaCO2, PaO2 and PH were not statistically significant in both the groups but with time the improvement in PaCO2 was better in IMV group when compared to NIV group. Conclusion: NIV leads to significant improvement in pulmonary parameters and it reduces duration of ventilation and total period of hospital stay, so it can be used as an alternative to invasive ventilation as first-line treatment in COPD.
- Subjects
NONINVASIVE ventilation; DISEASE exacerbation; CHRONIC obstructive pulmonary disease; RESPIRATORY insufficiency; ARTIFICIAL respiration
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 4, p1329
- ISSN
0975-3583
- Publication type
Article