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- Title
SCRUB TYPHUS; A RE-EMERGENT DISEASE: CLINICOPATHOLOGICAL PROFILE AND ITS PROGNOSIS IN A TERTIARY CARE CENTER IN KERALA.
- Authors
Zachariach, Sanjay; Prasad, Prasanth; Jinu C.; John, Jarlin; R., Abhijith Varma
- Abstract
Background: Scrub typhus, caused by the bacterium Orientia tsutsugamushi, is a vector-borne disease transmitted to humans through the bite of infected chiggers. It is endemic to the Asia-Pacific region and is associated with significant morbidity and mortality if left untreated. Methods: In this retrospective study, we analyzed the clinical features, laboratory findings, and complications in 40 patients diagnosed with scrub typhus at a tertiary care center between 2020-2022 Data were extracted from medical records and analyzed using descriptive and inferential statistics. Results: The study population comprised patients aged 17-75 years, with a relatively equal distribution across genders. Fever, headache, and myalgia were the most common presenting symptoms, while thrombocytopenia and leukocytosis were frequent laboratory findings. Complications such as acute kidney injury, hyponatremia, and hepatic injury were observed in a subset of patients. C-reactive protein (CRP) levels showed a significant positive correlation with total white count but not with the duration of fever or other clinical parameters. Conclusion: This study provides insights into the epidemiology, clinical presentation, and laboratory features of scrub typhus in our setting. The findings underscore the importance of early recognition and comprehensive management of scrub typhus to mitigate its morbidity and mortality. Further research is warranted to elucidate the pathophysiological mechanisms underlying the disease and improve diagnostic and treatment strategies.
- Subjects
PACIFIC Area; TSUTSUGAMUSHI disease; TERTIARY care; PROGNOSIS; ACUTE kidney failure; VECTOR-borne diseases; SYMPTOMS
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 3, p1562
- ISSN
0975-3583
- Publication type
Article