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- Title
CHARACTERIZATION AND ANTIFUNGAL SUSCEPTIBILITY PATTERN OF CANDIDA ISOLATES FROM VARIOUS CLINICAL SAMPLES: A CROSSSECTIONAL STUDY.
- Authors
Agarwal, Saumya; Jafar, Haniya; Chaturvedi, Priyanka; Katiyar, Shubham; Tiwari, Shubhangi; Prakash, Ved; Verma, Deepika; Garg, Ankur
- Abstract
Background: Candida spp are the most common opportunistic fungal pathogen causing infections in humans. In recent times, prevalence of candidiasis is on the rise due to indiscriminate use of antibiotics and steroids, AIDS and other immunosuppressive conditions. Some Candida spp. are intrinsically resistant to commonly prescribed antifungal drugs leading to treatment failure and episodes of recurrences. Moreover, emerging antifungal resistance in various Candida species has made the situation grievous. This mandates early identification and determination of antifungal susceptibility pattern of various Candida spp. Aim: To characterize Candida isolates and to determine their antifungal susceptibility pattern from various clinical samples at a tertiary care hospital. Material and methods: All isolates of Candida spp. isolated from various clinical specimens were included in this study. Speciation of Candida spp. Were performed by germ tube test, HiChrome agar, cornmeal agar and carbohydrate fermentation and assimilation. Antifungal susceptibility testing was done as per standard guidelines. Results: Out of total 229 Candida isolates, 28.8% were C. albicans and 71.2% were NAC. Among 163 non-albicans Candida spp.; C. tropicalis (103) was the most common isolate followed by C. glabrata (34), C. parapsilosis (19) and C. krusei (07). Susceptibility towards Fluconazole was found to be more in C. albicans as compared to NAC spp. In this study, NAC species also showed relatively reduced susceptibility to Amphotericin B. Conclusion: Prevalence of candidiasis is alarmingly increasing leading to significant morbidity and mortality. Various Candida spp. show difference in antifungal susceptibility attributing to treatment failure and episodes of recurrences. Early identification of Candida spp. and determination of their antifungal susceptibility pattern are crucial in selecting most appropriate antifungal drug for patient treatment.
- Subjects
CANDIDEMIA; CANDIDA; TREATMENT failure; CANDIDIASIS
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2023, Vol 14, Issue 9, p577
- ISSN
0975-3583
- Publication type
Article