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- Title
Ketone Monoester Followed by Carbohydrate Ingestion after Glycogen-Lowering Exercise Does Not Improve Subsequent Endurance Cycle Time Trial Performance.
- Authors
Quinones, Manuel D.; Weiman, Kyle; Lemon, Peter W. R.
- Abstract
Relative to carbohydrate (CHO) alone, exogenous ketones followed by CHO supplementation during recovery from glycogen-lowering exercise have been shown to increase muscle glycogen resynthesis. However, whether this strategy improves subsequent exercise performance is unknown. The objective of this study was to assess the efficacy of ketone monoester (KME) followed by CHO ingestion after glycogen-lowering exercise on subsequent 20 km (TT20km) and 5 km (TT5km) best-effort time trials. Nine recreationally active men (175.6 ± 5.3 cm, 72.9 ± 7.7 kg, 28 ± 5 y, 12.2 ± 3.2% body fat, VO2max = 56.2 ± 5.8 mL· kg BM−1·min−1; mean ± SD) completed a glycogen-lowering exercise session, followed by 4 h of recovery and subsequent TT20km and TT5km. During the first 2 h of recovery, participants ingested either KME (25 g) followed by CHO at a rate of 1.2 g·kg−1·h−1 (KME + CHO) or an iso-energetic placebo (dextrose) followed by CHO (PLAC + CHO). Blood metabolites during recovery and performance during the subsequent two-time trials were measured. In comparison to PLAC + CHO, KME + CHO displayed greater (p < 0.05) blood beta-hydroxybutyrate concentration during the first 2 h, lower (p < 0.05) blood glucose concentrations at 30 and 60 min, as well as greater (p < 0.05) blood insulin concentration 2 h following ingestion. However, no treatment differences (p > 0.05) in power output nor time to complete either time trial were observed vs. PLAC + CHO. These data indicate that the metabolic changes induced by KME + CHO ingestion following glycogen-lowering exercise are insufficient to enhance subsequent endurance time trial performance.
- Subjects
REPEATED measures design; FOOD consumption; DATA analysis; T-test (Statistics); COOLDOWN; BLIND experiment; STATISTICAL sampling; BLOOD collection; ENZYME-linked immunosorbent assay; KETONES; EXERCISE intensity; ERGOMETRY; RANDOMIZED controlled trials; DESCRIPTIVE statistics; 3-Hydroxybutyric acid; INSULIN; NUTRITIONAL requirements; CROSSOVER trials; METABOLITES; BLOOD sugar; SERUM; DRUG efficacy; ANALYSIS of variance; STATISTICS; DIETARY carbohydrates; ENDURANCE sports training; GLYCOGEN; BODY movement; OXYGEN consumption; DATA analysis software; DIETARY supplements; BIOMARKERS
- Publication
Nutrients, 2024, Vol 16, Issue 7, p932
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16070932