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- Title
Hematinic Potential of Olive Leaf Extract: Evidence from an In Vivo Study in Mice and a Pilot Study in Healthy Human Volunteers.
- Authors
Kondo, Shinji; Ferdousi, Farhana; Zhao, Jinchang; Suidasari, Sofya; Yokozawa, Miki; Yamauchi, Ken; Tominaga, Ken-ichi; Isoda, Hiroko
- Abstract
Natural resources have recently received considerable attention as complementary or alternative hematinic agents. In this regard, olive leaf extract, which is rich in bioactive phenolic compounds, has been reported to induce erythroid differentiation in human hematopoietic stem cells. Therefore, in the present study, we aimed to explore the potential hematinic properties of aqueous olive leaf extract (WOL) in vivo. After 24 days of administering WOL to healthy mice orally, red blood cell (RBC), hematocrit, reticulocyte, and reticulocyte hemoglobin content (CHr) showed a significant increase. Additionally, WOL promoted plasma iron levels and the expression of splenic ferroportin (Fpn), an iron transporter. Additionally, a single-arm pilot study involving a limited number of healthy volunteers was conducted to assess WOL's feasibility, compliance, and potential benefits. Following an 8-week intervention with WOL, RBC count and hemoglobin level were significantly increased. Notably, there were no significant changes in the safety measures related to liver and kidney functions. Furthermore, we identified oleuropein and oleuroside as the active components in WOL to induce erythroid differentiation in the K562 cell line. Altogether, our study presents evidence of the hematinic potential of WOL in the in vivo studies, opening up exciting possibilities for future applications in preventing or treating anemia.
- Subjects
ANEMIA prevention; PILOT projects; FLOW cytometry; HEMATOPOIETIC agents; IN vivo studies; RETICULOCYTES; ANALYSIS of variance; ANIMAL experimentation; ERYTHROPOIESIS; T-test (Statistics); LEAVES; RESEARCH funding; DESCRIPTIVE statistics; PLANT extracts; OLIVE; DATA analysis software; BIOLOGICAL assay; MICE; PHARMACODYNAMICS
- Publication
Nutrients, 2023, Vol 15, Issue 19, p4095
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15194095