We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Associations of Liver Function Parameters with New-Onset Hyperuricemia in a Large Taiwanese Population Study.
- Authors
Lu, Chun-Chi; Liu, Yi-Hsueh; Lee, Wen-Hsien; Chen, Szu-Chia; Su, Ho-Ming
- Abstract
Hyperuricemia is the chief cause of gout and has been linked with hypertension, cardiovascular and renal disease, diabetes and metabolic syndrome. Liver with the highest protein expression of xanthine oxidase, the main enzyme responsible for uric acid formation, is the primary site of uric acid biosynthesis. However, there are few studies that examine the association between liver function and new-onset hyperuricemia. Hence, using the Taiwan Biobank dataset, we aimed to explore the capability of liver function parameters, including gamma-glutamyl transferase, total bilirubin, albumin, alanine aminotransferase and aspartate aminotransferase in association with the subsequent development of hyperuricemia. We analyzed 21,030 participants without hyperuricemia at baseline. Hyperuricemia was defined as a uric acid concentration > 6.0 mg/dL in women or >7.0 mg/dL in men. New-onset hyperuricemia was defined as participants without baseline hyperuricemia having developed hyperuricemia upon subsequent exam. Overall, 1804 (8.6%) of the study subjects developed new-onset hyperuricemia. After multivariable analysis, significant associations were found between the male sex (odds ratio [OR], 4.412; p < 0.001), high values of systolic blood pressure (SBP) (OR, 1.006; p = 0.012), body mass index (BMI) (OR, 1.064; p < 0.001), fasting glucose (OR, 1.005; p < 0.001), triglycerides (OR, 1.001; p = 0.003), uric acid (OR, 5.120; p < 0.001), low values of estimated glomerular filtration rates (eGFR) (OR, 0.995; p < 0.001), total bilirubin (OR, 0.616; p < 0.001) and new-onset hyperuricemia. The cutoff level of total bilirubin, according to the Youden index, of receiver operating characteristic curve for identifying new-onset hyperuricemia was 0.65 mg/dL. Low total bilirubin was defined as ≤0.65 mg/dL. After multivariable analysis, we found a significant association between low total bilirubin level (≤0.65 mg/dL) (OR = 0.806; p < 0.001) and new-onset hyperuricemia. Our present study demonstrated that in addition to male sex, high SBP, BMI, fasting glucose, triglycerides, and uric acid and low eGFR, the serum's total bilirubin levels were negatively associated with new-onset hyperuricemia in a large Taiwanese cohort.
- Subjects
TAIWAN; GLUCOSE analysis; ANALYSIS of triglycerides; HYPERURICEMIA; LIVER function tests; ALBUMINS; FASTING; GLOMERULAR filtration rate; STATISTICS; REFERENCE values; TISSUE banks; MULTIVARIATE analysis; SYSTOLIC blood pressure; TAIWANESE people; DATABASE management; SEX distribution; DESCRIPTIVE statistics; URIC acid; ODDS ratio; BODY mass index; DATA analysis; RECEIVER operating characteristic curves; BILIRUBIN; ALANINE aminotransferase; ASPARTATE aminotransferase; DISEASE risk factors
- Publication
Nutrients, 2022, Vol 14, Issue 21, p4672
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14214672