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- Title
The Effect Insulin Therapy and Metformin on Osteoporosis in Diabetic Post-Menopausal Iraqi Women.
- Authors
Roomi, Ali B.; AL-Salih, Raid M. H.; Ali, Saher A.
- Abstract
The aim of this study is to evaluate the effects of insulin therapy and metformin on osteoporosis (OP) in diabetic post-menopausal women. In this study, 200 individuals, aged (50-73) year. Control and patients were divided to four groups, each group containing 50 patients. Group (CG) were healthy post-menopausal, group (OP) were post-menopausal with OP, group (T2D insulin) were post-menopausal with diabetic and treated insulin once daily and group (T2D-metformin) were post-menopausal with diabetic and treated metformin (500 mg) twice daily. The results revealed that fasting blood glucose (F.B.G), hemostatic model assessmentinsulin resistance (HOMO-IR), and bone mineral density (BMD) demonstrated a significant different in (T2D-insulin and T2D-metformin) group comparison with (OP) group. Serum insulin demonstrated a significant increase in (T2D-insulin) group comparison with (OP) group, While a significant reduce in (T2D-metfomin) group comparison with (OP) group. Whereas, the osteocalcin (OC) and carboxy-terminal telopeptides of type I collagen (CTXI) was a significant reduce in (T2D-insulin and T2D-metformin) group comparison with (OP) group. The final concluded that insulin therapy increases bone turnover biomarkers more than metformin therapy.
- Publication
Indian Journal of Public Health Research & Development, 2019, Vol 10, Issue 4, p1544
- ISSN
0976-0245
- Publication type
Article
- DOI
10.5958/0976-5506.2019.00935.5