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- Title
Using CAT score as a marker of severity in patients with Acute Exacerbation of COPD.
- Authors
Jha, Santosh K.; Agrawal, Ankur; Prabhudesai, Prahalad P.
- Abstract
Background&Method: The aim of this study is to evaluate the correlation between CAT score, mMRC score, Inflammatory markers and severity of COPD exacerbation was carried in Department of Respiratory Medicine, Lilavati Hospital and Research Centre, Mumbai. Study population and sample size was 75 patients (inpatients and outpatients) visiting Lilavati Hospital and Research Centre diagnosed with acute exacerbation in already proven cases of COPD on the basis of anthonisen criteria were enrolled in the study. Patients attending Pulmonary medicine OPD / in-patients of Lilavati Hospital and Research centre diagnosed as AECOPD (Clinician based diagnosis), satisfying the inclusion and exclusion criteria were included in study after written informed consent. Number of COPD exacerbations in the last 1 year, on bases of history given by patient was noted. And according to that they were divided in frequent and non frequent exacerbators. With frequent exacerbators having two or more than two exacerbations in the previous year. Also Patient's FEV1 on the basis of the last available spirometry report was noted and patient was characterized as per the GOLD criteria of COPD severity. Result: In our study 57 patients had two or more exacerbations in the previous year(frequent exacerbators) and 18 patients had less than 2 exacerbation in the previous year. It was found that CAT score was significantly higher in frequent exacerbators as compared to others. In frequent exacerbators CAT score mean was 30.35, and in non frequent exacerbators Mean CAT score was 25.89. Non-parametric correlation between pre-treatment values of various variables. CAT score and mMrc grades shows significant correlation. (p values <0.01). CRP and PCT levels also shows significant correlation.(p values <0.05). Conclusion:The CAT score is associated with the changes of systemic inflammation following exacerbations, and it is as responsive to the treatments as other measures such as mMrc dyspnea scale and inflammatory biomarkers. The CAT scores can reflect the health status of COPD patients, and are potentially useful to assess the treatments response following COPD exacerbations. The CAT is particular useful for health settings where access to other advance diagnostics are limited. CAT score was significantly higher at exacerbation in patients with history of frequent exacerbations. The CAT is particular useful for health settings where access to other advance diagnostics are limited. CAT score was significantly higher at exacerbation in patients with history of frequent exacerbations. CAT score not only includes dyspnea but also other components like cough, phlegm, chest tightness, limitation of daily activities, sleep quality and energy which makes it a better score for assessment of quality of life.
- Subjects
MUMBAI (India); DISEASE exacerbation; COUGH; SLEEP quality; CHRONIC obstructive pulmonary disease; PULMONOLOGY; SAMPLE size (Statistics)
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2021, Vol 12, Issue 6, p1797
- ISSN
0975-3583
- Publication type
Article