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- Title
Additional Resistance to any Fluoroquinolones among Multidrug-resistant Mycobacterium tuberculosis Isolates from North Coastal Andhra Pradesh, India.
- Authors
Suresh, Kancharla; Vimala, Yapadinna; Mohan, Nitin; Padmaja, Indugula Jyothi
- Abstract
Fluoroquinolones (FQ) are integral part of multidrug resistant/rifampicin resistant tuberculosis (MDRTB/RR TB) treatment regimens. FQ resistance in MDR-TB lead to narrower treatment options and poor treatment outcomes. Hence proportion of FQ resistance among MDR-TB and cross-resistance among FQ in MDR-TB isolates was studied. This is the first study from North Coastal Andhra Pradesh, India. A cross-sectional study was conducted on 21,474 sputum samples from January-December 2018 & 833 culture isolates (rifampicin resistant detected by GeneXpert MTB / RIF assay & MDR-TB detected by direct and indirect GenoType MTBDRplus Assay) were analysed for FQ resistance by Mycobacterium Growth Indicator Tube (MGIT) for ofloxacin (Ofx) 2.0 µg/mL, levofloxacin (Lfx) 1.5 µg/mL & moxifloxacin (Mfx) 2.0 µg/mL. Among 833 culture isolates, 119 (14.2%) showed resistance to FQ which included 90 (10.8%) Ofx and Lfx resistance isolates but still sensitive to Mfx, 16 (1.92%) with resistance to all FQ tested, 12 Ofx monoresistance & 1 Lfx monoresistance. Mfx monoresistance was absent. Mfx sensitive isolates are 714 (85.7%) and were always sensitive to Ofx and Lfx. Cross-resistance was not complete. MDR-TB/RR TB is 4.1% among all TB patients. Additional resistance to FQ, among MDR-TB patients was seen in 14.2% patients.
- Subjects
INDIA; MULTIDRUG-resistant tuberculosis; RIFAMPIN; FLUOROQUINOLONES; TUBERCULOSIS; MYCOBACTERIUM tuberculosis; TREATMENT effectiveness; MYCOBACTERIUM
- Publication
Journal of Pure & Applied Microbiology, 2021, Vol 15, Issue 1, p68
- ISSN
0973-7510
- Publication type
Article
- DOI
10.22207/JPAM.15.1.01