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- Title
MENOPAUZA KAO NEZAVISNI PREDIKTOR POVIŠENIH VREDNOSTI RETINOLVEZUJUĆEG PROTEINA 4 U SERUMU.
- Authors
Klisić, Aleksandra; Stanišić, Verica; Jovanović, Milovan; Kavarić, Nebojša; Ninić, Ana
- Abstract
Aim: Retinol-binding protein 4 (RBP4) is a novel adipokine closely related to insulin resistance. However, data on the influence of menopausal status on serum RBP4 are scarce. Therefore, the aim of the current study was to examine whether RBP4 levels are associated with menopausal status per se, independently of insulin resistance. Methods: A total of 30 premenopausal and 100 postmenopausal women non-treated with medications were included in the cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure (BP) were obtained. The homeostasis model assessment of insulin resistance (HOMA-IR) and estimated glomerular filtration rate (eGFR) were calculated. Results: Postmenopausal women displayed higher RBP4 and an unfavorable cardiometabolic profile, compared to premenopausal ones. Multiple linear regression analysis showed that in addition to high triglycerides level (beta=0.315; p=0.002), decreased eGFR (beta=-0.258; p=0.004) and high systolic BP (beta=0.418; p=0.028), menopause per se is an independent predictor of higher RBP4 levels (beta=0.240; p=0.016), (R2-adjusted=0.310; F=6,522; p<0.001). Conclusions: Serum RBP4 levels are dependent of menopausal status, which should be taken into account when examining the role of this adipokine in cardiometabolic diseases' occurrence.
- Publication
Timocki Medicinski Glasnik, 2017, Vol 42, Issue 4, p199
- ISSN
0350-2899
- Publication type
Article
- DOI
10.5937/tmg1704199k