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- Title
The Emerging Roles of Ferroptosis in Pathophysiology and Treatment of Acute Lung Injury.
- Authors
Wang, Yufei; Zhao, Zijun; Xiao, Zhaoyang
- Abstract
Ferroptosis, a programmed cell death discovered in recent years, is an iron-dependent lipid peroxidation accumulation. Unlike other modes of cell death (autophagy, necroptosis, pyroptosis, cuproptosis, etc.), ferroptosis has unique morphological characteristics and plays an important role in a variety of diseases. In recent years, there has been great progress in the study of ferroptosis. Studies have found that ferroptosis is associated with acute lung injury (ALI), a condition with a high mortality rate and limited treatment options. This paper summarizes the mechanism of ferroptosis from the perspectives of iron metabolism, lipid metabolism, amino acid metabolism, and glutathione metabolism. It also discusses the research progress of ferroptosis in ALI in order to find new directions for the prevention and treatment of this condition.
- Subjects
LUNG injuries; AMINO acid metabolism; APOPTOSIS; PATHOLOGICAL physiology; IRON metabolism; BLEPHAROPTOSIS
- Publication
Journal of Inflammation Research, 2023, Vol 16, p4073
- ISSN
1178-7031
- Publication type
Article
- DOI
10.2147/JIR.S420676