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- Title
Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic.
- Authors
Nicol, Dianne; Eckstein, Lisa; Morrison, Michael; Sherkow, Jacob S.; Otlowski, Margaret; Whitton, Tess; Bubela, Tania; Burdon, Kathryn P.; Chalmers, Don; Chan, Sarah; Charlesworth, Jac; Critchley, Christine; Crossley, Merlin; de Lacey, Sheryl; Dickinson, Joanne L.; Hewitt, Alex W.; Kamens, Joanne; Kazuto Kato; Kleiderman, Erika; Satoshi Kodama
- Abstract
The authors identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of clustered regularly interspersed short palindromic repeats (CRISPRs)-mediated somatic cell therapy. Topics mentioned include adequacy of regulatory processes in the context of somatic cell therapies, a list of specific regulatory uncertainties that require attention, and broader stakeholder engagement in risk assessment.
- Subjects
CRISPRS; SOMATIC cells; CELLULAR therapy; NUCLEOTIDE sequence; ETHICS committees
- Publication
Genome Medicine, 2017, Vol 9, p1
- ISSN
1756-994X
- Publication type
Article
- DOI
10.1186/s13073-017-0475-4