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- Title
The expression and activity of antioxidant enzymes in the liver of rats exposed to high-fructose diet in the period from weaning to adulthood.
- Authors
Glban, Alhadi M; Vasiljević, Ana; Veličković, Nataša; Nikolić ‐ Kokić, Aleksandra; Blagojević, Duško; Matić, Gordana; Nestorov, Jelena
- Abstract
BACKGROUND Increased fructose consumption correlates with rising prevalence of various metabolic disorders, some of which were linked to oxidative stress. The relationship between fructose consumption and oxidative stress is complex and effects of a fructose-rich diet on the young population have not been fully elucidated. The aim of this study was to investigate whether high-fructose diet applied in the period from weaning to adulthood induces oxidative stress in the liver, thus contributing to induction or aggravation of metabolic disturbances in later adulthood. To that end we examined the effects of high-fructose diet on expression and activity of antioxidant enzymes, markers of lipid peroxidation and protein damage in the liver as the main fructose metabolizing tissue. RESULTS High-fructose diet increased only SOD2 (mitochondrial manganese superoxide dismutase) activity, with no effect on other antioxidant enzymes, lipid peroxidation or accumulation of damaged proteins in the liver. CONCLUSION The results show that fructose-induced metabolic disturbances could not be attributed to oxidative stress, at least not at young age. The absence of oxidative stress in the liver observed herein implies that young organisms are capable of maintaining redox homeostasis when challenged by fructose-derived energy overload. © 2014 Society of Chemical Industry
- Subjects
LABORATORY rats; OXIDATIVE stress; ANTIOXIDANTS; FRUCTOSE; PEROXIDATION
- Publication
Journal of the Science of Food & Agriculture, 2015, Vol 95, Issue 11, p2319
- ISSN
0022-5142
- Publication type
Article
- DOI
10.1002/jsfa.6953