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- Title
Hypercalcemia and parathyroid hormone-related peptide expression in a dog with thyroid carcinoma and histiocytic sarcoma.
- Authors
Scruggs, Jennifer L.; Nobrega‐Lee, Michelle; Fry, Michael M.; Applegate, Rory
- Abstract
A 9.5-year-old, male castrated Walker Hound was presented for evaluation of progressive weakness, anorexia, and weight loss. Imaging revealed multiple abdominal and thoracic masses and ascites; fine-needle aspirates of mesenteric and splenic masses confirmed malignancy, most likely histiocytic sarcoma. Laboratory analyses revealed increased ionized calcium and parathyroid hormone-related peptide ( PTH- rP) concentrations, and concurrent low-normal parathyroid hormone concentration, consistent with humoral hypercalcemia of malignancy. Necropsy was performed after euthanasia. The dog had disseminated histiocytic sarcoma, including sarcomatosis, as well as bilateral thyroid carcinoma. PTH- rP immunostaining was positive in the thyroid carcinoma but negative in the histiocytic neoplasm. These results suggest that thyroid carcinoma-associated hypercalcemia can be caused by tumor secretion of PTH- rP.
- Subjects
DOG diseases; HYPERCALCEMIA; CALCIUM metabolism disorders; ANOREXIA nervosa; RETICULUM cell sarcoma
- Publication
Veterinary Clinical Pathology, 2015, Vol 44, Issue 2, p249
- ISSN
0275-6382
- Publication type
Article
- DOI
10.1111/vcp.12244