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- Title
Clinicopathologic features and prognosis of 51 patients with α-fetoprotein-producing gastric cancer.
- Authors
Liu Xiaoling; Yang Mudan; Gao Jan; Zhang Suzhen; Xi Yanfeng
- Abstract
Objective To analyze the clinicopathologic features and prognosis of α-fetoprotein ( AFP) -producing gastric cancers (AFPGC). Methods Fifty-one serum AFP-positive patients with positive in immunohistochemical staining of AFP in the primary lesions (study group) and sixty-five gastric cancer cases with normal AFP level (control group) treated in our department from January 2005 to December 2007 were included in this study. Their clinicopathologic features and follow-up data were statistically analyzed. Results Compared with die control group, die study group had a higher incidence of poorly differentiated adenocarcinoma (P =0.021 ) and liver metastasis (P = 0.001 ) than that in the control group. The TNM stages in the study group were significantly higher than those in the control group (P =0.001 ). The 1 -. 2-, and 5-year survival rates of the study group were 62. 7% , 27. 5% and 4. 7% , respectively, and the median survival was 16 months, significantly lower than the 84. 6%, 55. 4%, 16.5% , and 30 months of the control group (P<0.001 for all). The serum AFP levels in the study group ranged from 58.63 μg/L to 12 100.00 μg/L, and could be classified into two groups;27 cases <500 μg/L, and 24 cases ⩾500 μg/F. There was no significant difference of the in imunohistochemical staining results between the two subgroups ( P = 0.912). Conclusions AFPGC is a special type of gastric cancer with high degree of malignancy and poor prognosis. Monitoring of serum AFP level can earlier detect the progression of disease and give corresponding treatment.
- Publication
Chinese Journal of Oncology, 2015, Vol 37, Issue 3, p231
- ISSN
0253-3766
- Publication type
Article
- DOI
10.3760/cma.j.issn.0253-3766.2015.03.017