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- Title
Characterization of the Gene Expression Patterns in the Murine Liver Following Intramuscular Administration of Baculovirus.
- Authors
Iyori, Mitsuhiro; Ogawa, Ryohei; Emran, Talha Bin; Tanbo, Shuta; Yoshida, Shigeto
- Abstract
Intramuscular administration of wild-type baculovirus is able to both protect against Plasmodium sporozoite challenge and eliminate liver-stage parasites via a Toll-like receptor 9-independent pathway. To investigate its effector mechanism(s), the gene expression profile in the liver of baculovirus-administered mice was characterized by cDNA microarray analysis. The ingenuity pathway analysis gene ontology module revealed that the major gene subsets induced by baculovirus were immune-related signaling, such as interferon signaling. A total of 40 genes commonly upregulated in a Toll-like receptor 9-independent manner were included as possible candidates for parasite elimination. This gene subset consisted of NT5C3, LOC105246895, BTC, APOL9a/b, G3BP3, SLC6A6, USP25, TRIM14, and PSMB8 as the top 10 candidates according to the special unit. These findings provide new insight into effector molecules responsible for liver-stage parasite killing and, possibly, the development of a new baculovirus-mediated prophylactic and therapeutic biopharmaceutical for malaria.
- Subjects
GENE expression; GENE expression profiling; GENE regulatory networks; TOLL-like receptors; COMPLEMENTARY DNA; BIOPHARMACEUTICS; MALARIA; INTERFERON receptors
- Publication
Gene Expression (1052-2166), 2021, Vol 20, Issue 3, p147
- ISSN
1052-2166
- Publication type
Article
- DOI
10.3727/105221620X16039045978676