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- Title
Mapping the precision of genome editing.
- Authors
Gabriel, Richard; von Kalle, Christof; Schmidt, Manfred
- Abstract
The article comments on several research articles related to methods for identifying off-target double-strand breaks produced by CRISPR-associated (Cas)9 nucleases and transcription activator?like effector nucleases. Topics discussed include application of method that detects trapping of an integrase-defective lentiviral vector into doublestrand breaks by nonrestrictive linear amplification?mediated polymerase chain reaction, and use of high-throughput, genome-wide, translocation sequencing.
- Subjects
NUCLEASES; DNA structure; TAL effectors; POLYMERASE chain reaction; CHROMOSOMAL translocation
- Publication
Nature Biotechnology, 2015, Vol 33, Issue 2, p150
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt.3142