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- Title
A new furostanol saponin from Asparagus cochinchinensis.
- Authors
Shen, Yang; Xu, Cong-Li; Xuan, Wei-Dong; Li, Hui-Liang; Liu, Run-Hui; Xu, Xi-Ke; Chen, Hai-Sheng
- Abstract
A new furostanol saponin, (25S)-26-O-β- d-glucopyranosyl-5β-furost-20(22)-en-3β, 15β,26-triol-3-O-[α- l-rhamnopyranosyl-(1-4)]-β- d-glucopyranoside, namely, aspacochioside D ( 1) were isolated from Asparagus cochinchinensis (Lour.) Merr, along with three known saponins, aspacochioside C ( 2), (25S)-5β-spirostan-3β-yl-O-[O-α- l-rhamnopyranosyl-(1-4)]-β- d-glucopyranoside ( 3), and pseudoprotoneodioscin ( 4). The structure of 1 was elucidated on the basis of chemical reactions and spectral analysis (IR, GC, ESI-MS, H-NMR, C-NMR, DEPT, HMBC, HMQC and NOESY). The antiproliferative effects of 1-4 were evaluated in a cytotoxicity assay against the human tumor cell line, A549. Compound 2 (Aspacochioside C) exhibited moderate cytotoxicity against A-549, with an IC value of 3.87 μg/mL.
- Publication
Archives of Pharmacal Research, 2011, Vol 34, Issue 10, p1587
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-011-1001-7