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- Title
Synthesis and antinociceptive activity of (5-chloro-2(3 H)-benzoxazolon-3-yl) propanamide derivatives.
- Authors
Önkol, Tijen; Fethi Sahin, M.; Yildirim, Engin; Erol, Kevser; Ito, Shigero
- Abstract
In this study, (5-chloro-2(3 H)-benzoxazolon-3-yl)propanamide derivatives were synthesized. The chemical structures of the compounds were elucidated by their IR and1H-NMR spectral data and microanalysis. The compounds were tested for antinociceptive activity by using the tail clip, tail flick, hot plate, and writhing methods. The varying levels of antinociceptive activity of the compounds were compared with those of dipyrone and aspirin. Among these compounds, compound 5e, 5g, and 5h have been found to be significantly more active than the others and the standards in all the tests.
- Publication
Archives of Pharmacal Research, 2004, Vol 27, Issue 11, p1086
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02975109