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- Title
Outcomes after primary chemoradiotherapy for N3 (>6 cm) head and neck squamous cell carcinoma after an FDG-PET--guided neck management policy.
- Authors
Adams, Gerard; Porceddu, Sandro V.; Pryor, David I.; Panizza, Benedict; Foote, Matthew; Rowan, Ann; Burmeister, Bryan
- Abstract
ABSTRACT Background The purpose of this study was to assess whether a positron emission tomography (PET)-directed policy remains appropriate for managing neck nodes (N3; >6 cm) in head and neck squamous cell carcinoma (HNSCC). Methods All patients with N3 (>6 cm) HNSCC treated with definitive chemoradiotherapy (CRT) at our institution between 2005 and 2012 were included in the analysis. Patients underwent PET assessment before and 12 weeks after CRT. Neck dissections were performed for PET-avid residual nodal abnormalities after complete response at the primary site. Rate of isolated nodal failure (INF) was the primary outcome. Results Median follow-up from diagnosis for 33 patients was 30 months (range, 6−76 months). INF occurred in 2 patients (6%) with neck dissections performed in 4 cases (12%). First failure was predominantly distant metastatic (10; 30%). Conclusion The rate of INF remains low when following a PET-directed neck management policy after definitive CRT for N3 (>6 cm) HNSCC. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1200-1206, 2014
- Subjects
RADIOTHERAPY; CANCER chemotherapy; NECK injuries; SHRUNKEN heads; CLINICAL medicine; CANCER treatment; SQUAMOUS cell carcinoma; SURGERY; DIAGNOSIS
- Publication
Head & Neck, 2014, Vol 36, Issue 8, p1200
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23434