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- Title
Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure-and cholesterol-lowering effects.
- Authors
Park, Joon-Keun; Muller, Dominik N.; Mervaala, Eero M.A.; Dechend, Ralf; Fiebeller, Anette; Schmidt, Folke; Bieringer, Markus; Schafer, Olaf; Lindschau, Carsten; Schneider, Wolfgang; Ganten, Detley; Luft, Friedrich C.; Haller, Hermann
- Abstract
Examines the use of angiotensin II dependent model to test the ability of cerivastatin to prevent leukocyte adhesion and infiltration. Analysis on mitogen-activated protein kinase and transcription factor activation; Increase in inducible nitric oxied synthase expression in the endothelium vessels; Reduction of cell damage.
- Subjects
STATINS (Cardiovascular agents); NITRIC-oxide synthases; CELL adhesion
- Publication
Kidney International, 2000, Vol 58, Issue 4, p1420
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1046/j.1523-1755.2000.00304.x