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- Title
Mannitol therapy revisited (1940-1997).
- Authors
Better, Ori S.; Rubinstein, I.; Winaver, Joseph M.; Knochel, James P.
- Abstract
The purpose of the present article is to review the effect of mannitol on normal kidney function as well as its clinical therapeutic potential in the prevention of acute renal failure (ARF) and protection of skeletal muscle function following crush injury. Osmotic diuretics are freely filterable, low molecular weight substances that due to their limited reabsorption and small size create an osmotic force in the tubular fluid sufficient to retard the reabsorption of fluids and solutes along the nephron. Beyond its action as a diuretic agent, rnannitol has been used by many renal physiologists, over the past five decades as an important tool in the study of the mechanisms of salt and water transport at the tubular and cellular level.
- Subjects
KIDNEY diseases; DRUG therapy; ACUTE kidney failure; THERAPEUTICS; KIDNEY tubules; DIURETICS
- Publication
Kidney International, 1997, Vol 52, Issue 4, p886
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1997.409