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- Title
One-pot synthesis of β-amido ketones using Brønsted acidic ionic liquid as an efficient and reusable catalyst.
- Authors
Deshmukh, Krishna M.; Qureshi, Ziyauddin S.; Nandurkar, Nitin S.; Bhanage, Bhalchandra M.
- Abstract
An efficient protocol was developed for one-pot condensation of an aldehyde, ketone, acetyl chloride, and nitriles catalyzed by a stable and reusable 1-methyl-imidazolium hydrogen sulfate ([Hmim][HSO4]) as a Brønsted acidic ionic liquid. The system tolerated a variety of functional groups affording the corresponding β-amido ketones in moderate to good yields under milder operating conditions. On a développé un protocole efficace pour la condensation monotope d’un aldéhyde, d’une cétone, du chlorure d’acétyle et de nitriles, catalysée par un liquide ionique stable et réutilisable, le sulfate acide de 1-méthyl-imidazolium [Hmim][HSO4] qui agit comme acide de Brønsted. Le système tolère une grande variété de groupements fonctionnels conduisant à la formation des β-amidocétones correspondantes avec des rendements allant de modérés à bons, dans les conditions d’opération les plus douces.
- Subjects
CONDENSATION; ORGANIC compounds; IONIC liquids; FUNCTIONAL groups; NITRILES
- Publication
Canadian Journal of Chemistry, 2009, Vol 87, Issue 2, p401
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/V08-173