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- Title
Synthesis and fluorescence spectral studies of novel quinolylbenzothiazole-based sensors for selective detection of Fe<sup>3+</sup> ion.
- Authors
Wang, Peng; Liu, Xiaoyan; Fu, Jiaxin; Chang, Yongxin; Yang, Li; Xu, Kuoxi
- Abstract
Four novel fluorescence sensors bearing a quinolylbenzothiazole platform were synthesized and characterized. The sensors displayed excellent selectivity and highly sensitive fluorescence response to Fe3+ ion in H2O/DMSO buffer solution (1:4 volume ratio; Tris-HCl, 0.01 mol/L; pH = 7.40) at 500 nm originating from quinolylbenzothiazole fluorophore group. Other cations, namely Li+, Na+, K+, Mg2+, Ca2+, Co2+, Ni2+, Cd2+, Cu2+, Zn2+, Mn2+, Ba2+, Pb2+, Hg2+, Al3+, and Eu3+, showed no appreciable change in fluorescence spectrum. The binding stoichiometry between sensors <bold>L1</bold>, <bold>L2</bold>, <bold>L3</bold>, or <bold>L4</bold> and Fe3+ was observed to be 1:1 based on fluorescence titration and Jobs plot analysis. The detection limits of <bold>L1</bold>, <bold>L2</bold>, <bold>L3</bold>, and <bold>L4</bold> for Fe3+ were found to be 0.155, 0.362, 0.249, and 0.517 μmol/L, respectively. Furthermore, possible utilization of sensors to detect Fe3+ in living HeLa cells was also investigated by confocal fluorescence microscopy. <graphic></graphic>
- Subjects
FLUORESCENCE microscopy; BENZOTHIAZOLE; HELA cells; STOICHIOMETRY; TRACE elements; GENETIC speciation
- Publication
Canadian Journal of Chemistry, 2018, Vol 96, Issue 8, p835
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2017-0741