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- Title
Association Between Triglycerides, High-Density Lipoprotein Cholesterol, and Their Ratio With the Pulse Wave Velocity in Adults From the ELSA-Brasil Study.
- Authors
Lelis, Deborah de Farias; Cunha, Roberto S.; Santos, Raul D.; Sposito, Andrei C.; Griep, Rosane Härter; Barreto, Sandhi Maria; Molina, Maria del Carmen B.; Schmidt, Maria Inês; Duncan, Bruce B.; Bensenor, Isabela; Lotufo, Paulo Andrade; Mill, José Geraldo; Baldo, Marcelo Perim
- Abstract
Atherogenic dyslipidemia is a risk factor for cardiovascular diseases. The present study aimed to evaluate the association between triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and the triglycerides to high-density lipoprotein (TG/HDL-C) ratio with carotid-femoral pulse wave velocity (cf-PWV), a marker of vascular stiffness. Anthropometric, biochemical, and clinical data from 13,732 adults were used to assess this association. Individuals within the third TG/HDL-C tertile presented worse anthropometric, biochemical, and clinical profiles as compared with the participants in the lower TG/HDL-C tertile. There was a linear association between TG, HDL-C, and TG/HDL-C ratio and cf-PWV in both men and women (stronger in women). After adjustment for confounders, lower levels of HDL-C were associated with increased cf-PWV in men (9.63 ±.02 m/s) and women (8.90 ±.03 m/s). However, TG was not significantly associated with cf-PWV after adjustment, regardless of sex. An increased TG/HDL-C ratio is associated with higher cf-PWV only in women (9.01 ±.03 m/s), but after adjustment for HDL-C levels, the association was non-significant (8.99 ±.03 m/s). These results highlight the stronger association of HDL-C with arterial stiffness, and that the association of TG/HDL-C with cf-PWV is dependent on HDL-C.
- Subjects
TRIGLYCERIDES; HDL cholesterol; ANTHROPOMETRY; ARTERIAL diseases; DESCRIPTIVE statistics
- Publication
Angiology, 2023, Vol 74, Issue 9, p822
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/00033197221121434