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- Title
Comparison Among Bone Marrow and Wheat Flour's Mixture and Standard Treatment on Healing Second-Degree Burn Wound in Rats.
- Authors
Jafari, Saboreh; Jalali, Rostam; Jalili, Cyrus; Jamshidpoor, Tahereh
- Abstract
The treatment of extensive skin burns remains as a challenge for health care personnel. This study aimed to compare the combination of bone marrow and wheat flour with standard treatment on animal models. In this experimental study, 45 male rats were randomly assigned into three groups as follows: The first group was control (no treatment), the second group received bone marrow and wheat flour combination topically, and the third group received standard treatment (1% silver sulfadiazine). The treatment lasted for up to 21 days. On the 22nd day, the rats were killed. The number of blood vessels and hair follicles was measured in the burn wound bed. The area and depth of the wound were also measured. Data were analyzed using SPSS software version 16. The results showed that, complete closure of the wound was better in the bone marrow treated group compared with the group receiving the silver sulfadiazine and the control group. Furthermore, the wound healing was better in the silver sulfadiazine group compared with the control group. Microscopic examination revealed a significant increase in the number of hair follicles and blood vessels in the bone marrow and silver groups compared with the control group. The results showed that, the group treated with bone marrow, because of the presence of mesenchymal and stem cells can cause stimulating angiogenesis and producing vegetative tissue, hence it improved maturation, shrinkage, and contraction of the wound in comparison with the silver sulfadiazine and control groups.
- Subjects
MEDICAL personnel; BONE marrow; FLOUR; HEALING; SILVER sulfadiazine; TREATMENT for burns &; scalds; WOUND healing; RESEARCH; BACTERICIDES; ANIMAL experimentation; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; RATS; COMPARATIVE studies; FOOD; SOFT tissue injuries
- Publication
Journal of Burn Care & Research, 2021, Vol 42, Issue 2, p288
- ISSN
1559-047X
- Publication type
journal article
- DOI
10.1093/jbcr/iraa144