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- Title
THE EFFECTS OF GRAPE LEAVES EXTRACT ON HYPERHOMOCYSTEINEMIA INDUCED INFLAMMATORY ENDOTHELIAL DAMAGE IN CARDIOVASCULAR DISEASES.
- Authors
FERHI, S.; ZERIZER, S.; D’HALLEWIN, G
- Abstract
This study was designed to detect the anti-oxidant and anti-inflammatory effects of phenolic compounds in grape leaves Algerian variety (GLAV) on endothelial damage. The phenolics were identified by using HPLC/DAD/ESI-MS analysis. The research of the anti-oxidant and anti-inflammatory effects was conducted on mice through 15 days. Results showed high levels of phenols, anthocyanins, flavonols and trans-caftaric acid in GLAV. The plasma hs-CRP and homocysteine levels were elevated significantly (p < 0.05) however the glutathione reduced significantly (p < 0.05) after the administration of L-methionine in high doses to mice. This was associated with the desquamation of endothelium and muscular lysis with transformation of spindle nuclei to oval nuclei; this is due to the angiotoxic action of homocysteine on the aorta. These changes were not observed in mice treated with L-methionine plus the antioxidant and anti-inflammatory extract of GLAV. So, the study proved the antioxidant and antiinflammatory effects of the GLAV on hyperhomocysteinemia induced inflammatory endothelial damage in cardiovascular diseases.
- Publication
Applied Ecology & Environmental Research, 2019, Vol 17, Issue 2, p1989
- ISSN
1589-1623
- Publication type
Academic Journal
- DOI
10.15666/aeer/1702_19892003