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- Title
Biological and medical applications of plasma-activated media, water and solutions.
- Authors
Kaushik, Nagendra Kumar; Ghimire, Bhagirath; Li, Ying; Adhikari, Manish; Veerana, Mayura; Kaushik, Neha; Jha, Nayansi; Adhikari, Bhawana; Lee, Su-Jae; Masur, Kai; von Woedtke, Thomas; Weltmann, Klaus-Dieter; Choi, Eun Ha
- Abstract
Non-thermal atmospheric pressure plasma has been proposed as a new tool for various biological and medical applications. Plasma in close proximity to cell culture media or water creates reactive oxygen and nitrogen species containing solutions known as plasma-activated media (PAM) or plasma-activated water (PAW) – the latter even displays acidification. These plasma-treated solutions remain stable for several days with respect to the storage temperature. Recently, PAM and PAW have been widely studied for many biomedical applications. Here, we reviewed promising reports demonstrating plasma-liquid interaction chemistry and the application of PAM or PAW as an anti-cancer, anti-metastatic, antimicrobial, regenerative medicine for blood coagulation and even as a dental treatment agent. We also discuss the role of PAM on cancer initiation cells (spheroids or cancer stem cells), on the epithelial mesenchymal transition (EMT), and when used for metastasis inhibition considering its anticancer effects. The roles of PAW in controlling plant disease, seed decontamination, seed germination and plant growth are also considered in this review. Finally, we emphasize the future prospects of PAM, PAW or plasma-activated solutions in biomedical applications with a discussion of the mechanisms and the stability and safety issues in relation to humans.
- Subjects
PLASMA gases; ATMOSPHERIC pressure; CULTURE media (Biology); REGENERATIVE medicine; ANTINEOPLASTIC agents; ACIDIFICATION
- Publication
Biological Chemistry, 2019, Vol 400, Issue 1, p39
- ISSN
1431-6730
- Publication type
Article
- DOI
10.1515/hsz-2018-0226