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- Title
Absolute quantification of perfusion by dynamic susceptibility contrast MRI using Bookend and VASO steady-state CBV calibration: a comparison with pseudo-continuous ASL.
- Authors
Lindgren, Emelie; Wirestam, Ronnie; Markenroth Bloch, Karin; Ahlgren, André; Osch, Matthias; Westen, Danielle; Surova, Yulia; Ståhlberg, Freddy; Knutsson, Linda
- Abstract
Objective: Dynamic susceptibility contrast MRI (DSC-MRI) tends to return elevated estimates of cerebral blood flow (CBF) and cerebral blood volume (CBV). In this study, subject-specific calibration factors (CFs), based on steady-state CBV measurements, were applied to rescale the absolute level of DSC-MRI CBF. Materials and methods: Twenty healthy volunteers were scanned in a test-retest approach. Independent CBV measurements for calibration were accomplished using a T1-based contrast agent steady-state method (referred to as Bookend), as well as a blood-nulling vascular space occupancy (VASO) approach. Calibrated DSC-MRI was compared with pseudo-continuous arterial spin labeling (pCASL). Results: For segmented grey matter (GM) regions of interests (ROIs), pCASL-based CBF was 63 ± 11 ml/(min 100 g) (mean ± SD). Nominal CBF from non-calibrated DSC-MRI was 277 ± 61 ml/(min 100 g), while calibrations resulted in 56 ± 23 ml/(min 100 g) (Bookend) and 52 ± 16 ml/(min 100 g) (VASO). Calibration tended to eliminate the overestimation, although the repeatability was generally moderate and the correlation between calibrated DSC-MRI and pCASL was low ( r < 0.25). However, using GM instead of WM ROIs for extraction of CFs resulted in improved repeatability. Conclusion: Both calibration approaches provided reasonable absolute levels of GM CBF, although the calibration methods suffered from low signal-to-noise ratio, resulting in weak repeatability and difficulties in showing high degrees of correlation with pCASL measurements.
- Subjects
CEREBRAL circulation; CONTRAST media; MAGNETIC resonance imaging of the brain; POSITRON emission tomography; SIGNAL-to-noise ratio
- Publication
MAGMA: Magnetic Resonance Materials in Physics, Biology & Medicine, 2014, Vol 27, Issue 6, p487
- ISSN
0968-5243
- Publication type
Article
- DOI
10.1007/s10334-014-0431-x