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- Title
Seizure in Alzheimer's Disease: An Underestimated Phenomenon.
- Authors
Asadollahi, Marjan; Atazadeh, Musa; Noroozian, Maryam
- Abstract
Alzheimer's disease (AD) is considered as a potential risk factor for the development of seizure due to neurodegeneration and imbalance between stimulatory and inhibitory circuits in the brain. Seizure could occur in any point during the course of AD, and its presentation varies from fluctuation in cognitive domains to more typical seizures. The clinical diagnosis of seizure in patients with dementia may be challenging due to difficulty in history taking and clinical assessment. No paraclinic methods other than electroencephalogram (EEG) could provide arguments for the diagnosis of AD-related seizures (neither imaging modalities nor cerebrospinal fluid biomarkers). Standard 30-minute EEG may not be sufficiently sensitive to detect epileptiform discharges. In the present study, we aim to review different aspects of seizure in AD, including seizure prevalence, risk factors, underlying mechanisms, electroencephalographic findings, clinical presentations, impact of seizures on AD, and treatment options.
- Subjects
SEIZURES diagnosis; DIAGNOSIS of dementia; SPASM treatment; CONVULSIONS -- Risk factors; RISK factors of spasms; ALZHEIMER'S disease; BIOMARKERS; COGNITION; ELECTROENCEPHALOGRAPHY; SEIZURES (Medicine); MEDICAL needs assessment; MEDICAL history taking; DISEASE prevalence; SPASMS; DISEASE complications; SYMPTOMS; DIAGNOSIS; THERAPEUTICS
- Publication
American Journal of Alzheimer's Disease & Other Dementias, 2019, Vol 34, Issue 2, p81
- ISSN
1533-3175
- Publication type
Article
- DOI
10.1177/1533317518813551