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- Title
Use of PET/CT and Stereotactic Radiation Therapy for the Diagnosis and Treatment of Osteosarcoma Metastases.
- Authors
Selmic, Laura Elizabeth; Griffin, Lynn R.; Nolan, Michael W.; Custis, James; Randall, Elissa; Withrow, Stephen J.
- Abstract
This case report describes the use of two new concepts in the diagnosis and treatment of metastatic osteosarcoma (OSA) in one dog. The dog was initially presented for positron emission tomography and computed tomography (PET/ CT) as full-body staging following amputation and adjuvant chemotherapy for treatment of OSA of the proximal tibia. The initial PET/CT did not show evidence of metastatic disease. Six mo after OSA, diagnosis pulmonary metastatic nodules were identified and oral toceranib phosphate was initiated. Twelve mo postdiagnosis the dog developed neck pain and non-ambulatory tetraparesis and was diagnosed with a C7 vertebral metastatic lesion based on magnetic resonance imaging. A second PET/CT was performed to screen for further metastatic lesions, and a nodule within the right ischium was identified. The C7 and ischial lesions were treated with stereotactic radiation therapy (SRT). Sixteen mo postdiagnosis, a third PET/CT was performed due to increasing size of the pulmonary nodules and a right-sided liver metastasis was detected. The liver mass was treated with SRT. The PET/CT scans facilitated identification of gross metastatic lesions that were subsequently treated with SRT, which resulted in clinical improvement of the dog's neurological signs.
- Subjects
OSTEOSARCOMA in dogs; POSITRON emission tomography; POSITRON emission; COMPUTED tomography; OSTEOSARCOMA; THERAPEUTICS
- Publication
Journal of the American Animal Hospital Association, 2017, Vol 53, Issue 1, p52
- ISSN
0587-2871
- Publication type
Case Study
- DOI
10.5326/JAAHA-MS-6359