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- Title
One-step labelling of a novel small-molecule peptide with astatine-211: preliminary evaluation in vitro and in vivo.
- Authors
Liu, Weihao; Ma, Huan; Tang, Yu; Chen, Qing; Peng, Shuqun; Yang, Jijun; Liao, Jiali; Yang, Yuanyou; Li, Qianwei; Liu, Ning
- Abstract
In this paper, VP2, a novel small molecule fusion peptide, was labelled with 211At through a one-step method (coupled with bifunctional intermediate SPC first and then labelled) with a radiochemical yield of about 45%. The radiochemical purity was still > 95% after 24 h at room temperature. Specificity studies in vitro indicated that 211At-SPC-VP2 has a high affinity for several tumour cells. Additionally, biodistribution in KM mice showed that 211At-SPC-VP2 has sufficient stability in vivo. This research suggested that 211At-SPC-VP2 produced by the convenient method has the potential to be a novel targeted drug for cancer radiotherapy.
- Subjects
SMALL molecules; ASTATINE; CANCER radiotherapy; NANOPARTICLES; RADIOPHARMACEUTICALS
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2018, Vol 316, Issue 2, p451
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-018-5780-x