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- Title
Preparation and mechanism of hydroxyapatite hollow microspheres with different surface charge by biomimetic method.
- Authors
Yang, Xiuying; Tian, Zhenzhen; Guo, Kebing; Lu, Ting; Ji, Jingou; Hao, Shilei; Xiao, Shangyou
- Abstract
To meet the different application requirements in various fields, hydroxyapatite (HA) hollow microspheres with different surface charge were synthesized successfully by biomimetic method using Ca(NO3)2·4H2O and (NH4)2HPO4 in the presence of polyethylene glycol (PEG). Scanning electron microscopy (SEM), High-resolution TEM (HRTEM), X-ray powder diffraction (XRD), and Zeta PALS were used to characterize the obtained samples. The results indicated that the concentration of PEG and temperature significantly affect the morphology of the obtained samples. After incubation for 5 d, the HA hollow microspheres with positive surface charge, HA spherical nanoparticles with surface charge close to zero and calcium deficiency HA (d-HA) hollow microspheres with negative surface charge were obtained respectively in the presence of 5% PEG, 6% PEG and 7% PEG at 15 °C. Brunauer-Emmett-Teller (BET) revealed that the specific surface area of HA hollow microspheres reached 98.50 m2/g, while that of HA spherical nanoparticles were only 4.12 m2/g, hollow microspheres show a better application prospect. The possible formation mechanism was also discussed.
- Subjects
MICROSPHERES; X-ray powder diffraction; POLYETHYLENE glycol; SCANNING electron microscopy; SURFACE charges; SURFACE area; NANOPARTICLES
- Publication
Journal of Materials Science: Materials in Medicine, 2020, Vol 31, Issue 5, p1
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-020-06385-7