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- Title
Carboxymethyldextran/magnetite hybrid microspheres designed for hyperthermia.
- Authors
Miyazaki, Toshiki; Anan, Shota; Ishida, Eiichi; Kawashita, Masakazu
- Abstract
Recently, organic-inorganic hybrids composed of derivatives of dextran, a polysaccharide, and magnetite nanoparticles have attracted much attention as novel thermoseeds. If they can be fabricated into microspheres of size 20-30 μm, they are expected to show not only hyperthermia effects but also embolization effects in human liver and kidney cancers. In this study, we examined the fabrication of carboxymethyldextran/magnetite microspheres using a water/oil emulsion as the reaction medium. Improvement of the chemical stability of the microcapsules by coating with silica using a sol-gel process was also investigated. The obtained hollow microspheres contained particles of size 20-30 μm. Silica coating using an appropriate catalyst for hydrolysis and polycondensation of alkoxysilanes was found to be effective for preventing dissolution and collapse in simulated body environments.
- Subjects
MAGNETITE; MICROSPHERES; FEVER; DEXTRAN; THERAPEUTIC embolization; HYDROLYSIS; POLYCONDENSATION; ALKOXYSILANES; THERAPEUTICS
- Publication
Journal of Materials Science: Materials in Medicine, 2013, Vol 24, Issue 5, p1125
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-013-4874-9