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- Title
Copper(I)‐Catalyzed Highly Enantioselective [3+3]‐Cycloaddition of β‐Aryl/Alkyl Vinyl Diazoacetates with Nitrones.
- Authors
Zheng, Haifeng; Faghihi, Isa; Doyle, Michael P.
- Abstract
β‐Aryl/alkyl vinyl diazoacetates were investigated in metallo‐vinylcarbene reactions with nitrones, revealing a Rh2(OAc)4‐catalyzed cyclopropene dimerization reaction and a copper(I) catalyzed [3+3]‐cycloaddition of nitrones. The chiral cyclopropyl‐In‐SaBox ligand with copper(I) catalysis could realize the asymmetric version of the cycloaddition reaction, delivering various 3,6‐dihydro‐1,2‐oxazine derivatives in good yield and with excellent enantioselectivity under mild conditions.
- Subjects
NITRONES; ISOXAZOLIDINES; COPPER; CYCLOPROPENE; CATALYSIS; RING formation (Chemistry); DIMERIZATION
- Publication
Helvetica Chimica Acta, 2021, Vol 104, Issue 7, p1
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.202100081