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- Title
Design and Synthesis of Some Novel 2,3,4,5-Tetrahydro-1 H-pyrido[4,3- b]indoles as Potential c-Met Inhibitors.
- Authors
Ye, Lianbao; Tian, Yuanxin; Li, Zhonghuang; Zhang, Jiajie; Wu, Shuguang
- Abstract
Since deregulation of the tyrosine-kinase receptor c-Met is implicated in several human cancers and is an attractive target for small-molecule-drug discovery, we report herein the synthesis of 2,3,4,5-tetrahydro-8-[1-(quinolin-6-ylmethyl)-1 H-1,2,3-triazolo[4,5- b]pyrazin-6-yl]-1 H-pyrido[4,3- b]indoles 4a- 4c and 2,3,4,5-tetrahydro-8-[3-(quinolin-6-ylmethyl)-1,2,4-triazolo[4,3- b]pyridazin-6-yl]-1 H-pyrido[4,3-b]indoles 5a- 5c. These indole derivatives demonstrated inhibition of c-Met kinase activity. Concurrently, five key intermediates were synthesized. These compounds could be prepared in good yields.
- Subjects
INDOLE; LIVER cells; GROWTH factors; PHOSPHORYLATION; CHEMICAL reactions
- Publication
Helvetica Chimica Acta, 2012, Vol 95, Issue 2, p320
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201100226